Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice
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چکیده
منابع مشابه
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study
INTRODUCTION Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS A total of 24 female Sprague-Dawley rats (200-250 g) were ...
متن کاملHIF-1α change in serum and callus during fracture healing in ovariectomized mice.
The purpose was to detect the effects of ovariectomy (OVX) on femoral fracture healing through different angiogenesis and HIF-1α expression in mice. Thirty-six young female C57 mice were randomized into two groups: OVX and age-matched intact control (CON). The femoral fracture was generated at 3 weeks after OVX or CON. At 2 or 4 weeks after fracture, the femoral fracture area was evaluated heal...
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METHODS: The study protocol was approved and followed by the Institutional Animal Care and Use Committee of the author’s institution. Twentyfour rabbits received unilateral, transverse, mid-tibial, 3-mm gapped osteotomies that were stabilized with double-bar external fixators. With the aim to simulate the venous stasis and soft tissue edema that is common to acute tibial fractures, the left fem...
متن کاملHyperhomocysteinemia disturbs fracture healing in mice
INTRODUCTION: Homocysteine (HCY) is the degradation product of the essential amino acid methionine. HCY is either metabolized to cysteine and glutathione by a vitamin B6 dependent pathway or remethylated to methionine by a vitamin B12 and folate dependent pathway. In the Western world hyperhomocysteinemia (HHCY) represents a widespread metabolic disorder leading to atherosclerosis and osteoporo...
متن کاملHyperbaric Hyperoxia Accelerates Fracture Healing in Mice
Increased oxygen tension influences bone metabolism. This study comprised two main experiments: one aimed to determine the bone mineral apposition and bone formation rates in vivo under hyperbaric hyperoxia (HBO), and the other aimed to evaluate the effects of exposure to HBO on fracture healing. In experiment 1, male mice were exposed to HBO [90 min/day at 90% O₂ at 2 atmospheres absolute (ATA...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2018
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2018.6353